BIOINFORMATIK
Forschungsgruppe Life science informatics an der THD
General Information
How much Information is inside us?
The human genome contains ~3 billion letters in almost every one of the 100 trillion cells. Techniques in biomedical research and molecular diagnostics enable to read out and analyze this sequence of letters, to identify errors and thus the cause of certain diseases, and to treat them in a targeted manner. And what do you need to actually do this - Bioinformatics? For me, probably the most fascinating, but also challenging work of all.
Computational biology has developed rapidly in the last decades and continues to do so. Bioinformatics deals not only with sequencing data, but also with molecular structures, enzymatic activities, medical and pharmacological statistics, to name just a few topics. Nevertheless, especially the analysis of biological sequences has become a very important part of bioinformatics, both in the natural sciences and in medicine. Especially in molecular diagnostics, precision medicine and personalized medicine it has become indispensable. Dealing professionally with Next Generation Sequencing data and being able to answer specific research questions about sequencing data requires biomedical as well as informatics skills.
What ist Next Generation Sequencing?
The Next Generation Sequencing (NGS) technology produces large amounts of data of the (human) genome, epigenome and associated transcriptome, the analysis and interpretation of which is a growing challenge. Therefore, it is important to create a functional and resilient interface between natural scientists and computer scientists. The volumes of data generated in the decoding of human, animal or plant genomes, for example, must be processed and correlated in order to make them useful.
Biomedical research and molecular diagnostics are currently using a variety of computational analysis tools to identify and analyze genes that are predictive of prognosis or therapeutic response with respect to a disease (precision medicine, personalized medicine). The analysis and evaluation of these data sets requires knowledge in the field of biomedicine combined with application-oriented informatics. Exactly these core competences are necessary to perform a high-quality and meaningful data analysis - transparent and comprehensible.
Fachgruppen:
PRojects
In this study RNA-sequencing data of resistant and susceptible plant individuals is analysed for regulated gene expression. Differentially expressed genes were identified and a possible correlation between their biochemical function and a resistance against plant infection was found.
An RNA-sequencing experiment can show up a high number of regulated genes. In collaboration with our partners and dependant on the nature of used data biological relevant effects in the sequenced biosamples are investigated. Frequently, the collaboration of "molecular cell biology" labs and bioinformatic analyses leads to linking points for further experimentl studies.
"Molecular mechanisms of differential transcriptional activity of AP-1 factors c-Jun, Fra-1, and ATF-2, and their functional significance in malignant melanoma."
PArtner
Prof. Dr. Anja Bosserhoff
Lehrstuhlinhaberin Biochemie und Molekulare Medizin
email: anja.bosserhoff@fau.de
Institut für Biochemie, Emil Fischer Zentrum
Fahrstraße 17 D-91054 Erlangen
Prof. Dr. Michael Rehli
RCI Regensburger Centrum für Interventionelle Immunologie
c/o Universitätsklinikum Regensburg
Franz-Josef-Strauß-Allee 11
D-93053 Regensburg
email: michael.rehli@ukr.de
Prof. Dr. Ralph Marienfeld
Institute of Pathology
University Medical Center Ulm
89070 Ulm
ed.mlu-kinilkinu@dlefneiram.flar
Prof. Dr. Andreas Wieser, Dr. Alexander Stolz, Dr. Susanna Oswald
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Immunology, Infection and Pandemic Research IIP
Türkenstraße 87
80799 Munich
Germany
Wieser@mvp.lmu.de, Susanna.Oswald@itmp.fraunhofer.de, Alexander.Stolz@itmp.fraunhofer.de
Dr. Josef Scheiber
BioVariance GmbH
Konnersreuther Sr. 6g
95652 Waldsassen
Contact: josef.scheiber@biovariance.com
MVZ Klinikum Deggendorf GmbH, Abteilung Onkologie
Perlasberger Straße 41
94469 Deggendorf
DONAUISAR Klinikum Deggednorf-Dingolfing- Landau gKu
Perlasberger Straße 1
94469 Deggendorf
Abteilung Molekularpathologie des Institutes für Pathologie und Zytologie am DONAUISAR KLINIKUM Deggendorf
Perlasberger Straße 41
94469 Deggendorf
PD Dr.rer.nat. Ralph Fingerhut
Leitung Neugeborenenscreening
SYNLAB MVZ Weiden GmbH
Zur Kesselschmiede 4
92637 Weiden / Germany
Lab Translational Biomedicine
Since recently the institute established a new molecular cell biology laborartory. Biosampling, DNA, RNA and protein isolation, modifciation, measurement/detection and many more can be performed. This lab is used as a teaching lab in the current study programs in the field of bioinformatics. Recent scientific work is also performed.